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We identified eligible studies indexed in Embase, PubMed, and the Cochrane Library databases, published in any language, and containing data from the inception of the study to March 14, 2022 (Fig

A derivative of histidine (2-mercapto-histidine trimethylbetaine) (Reference Barger and Ewins1,Reference Heath and Toennies2) , ergothioneine, was first isolated in 1909 from the ergot fungus Claviceps purpurea , from which its name was derived (Reference Tanret3)

doi: 10.1016/S1474-4422(14)70262-5 88 HyungS

Reduced inflammation: Both molecules suppress inflammatory pathways through different mechanismsNAD+ via sirtuin activation and glutathione via NF-B modulationfor comprehensive inflammation control

Additionally, two independent observers extracted data and resolved differences by discussion to maintain the validity and reliability

As believed, the dexpanthenol moisturizing effect is also linked to the ability to regenerate the epidermal barrier through increased epithelial differentiation and lipid synthesis