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This was revealed in about 10% to 25% of patients in Western countries however was significantly lower (less than 5%) in Asian countries [95]

10.3390/toxics10010011 24 DominguesR

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Thats why therapies like KPV peptide are so promising

However, the approach was also used for the improvement of brain delivery of therapeutic agents with extracellular targets including a neurotransmitter dopamine, competitive antagonist of the glycine site of the NMDA receptor 7-chlorokynurenic acid, serotonin-norepinephrine reuptake inhibitor venlafaxine and inhibitor of the GABA transporter nipecotic acid (Table II, III)

259 Numerous studies have shown that TLR2 stimulation by parenteral or mucosal treatment with synthetic agonists prevents APCs from triggering Th2-polarizing responses, reducing IgE antibodies and immunogenicity in a mouse model of asthma