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In addition, the use of bacteria as carriers to deliver drugs to tumors and other lesions, or to modify bacteria to express or deliver targeted drugs will greatly improve the therapeutic effect (39, 45, 46)

hTRX can function directly by interacting with the target molecules such as NFKB transcription factor, or indirectly via another redox protein known as redox factor 1 (Ref-1 )

[4] Eli Lilly and Company

Werenberg Dreier J, Nybo Andersen AM, Hvolby A, Garne E, Kragh Andersen P, Berg-Beckhoff G

ROS-induced apoptosis also explains the beneficial effect of two analogs of nuclear receptor ligands in several types of cancer: 2-methoxyestradiol, a 17-estradiol metabolite, and N-(4-hydroxyphenyl) retinamide, a synthetic analog of retinoic acid, have been shown to induce PCD in neuroblastoma and lung cancer cells, respectively 104,105