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This finding is intriguing because human glutathione synthetase deficiency, a heritable amino acid metabolism disorder, also leads to hyperaccumulation of pyroglutamic acid resulting in high anion gap metabolic acidosis a form of acidosis defined by acid accumulation and low pH of the blood 48

Indeed, if the GSTM2 enzyme catalyses the breakdown of this conjugate in a manner comparable to that of GSTM1, the functional similarity between these two isozymes would be established

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these effects are attributed to paracrine-mediated signaling within the ovarian microenvironment (170, 171)

Dietary administration of broccoli seeds induced a significant increase in activities of the phase II detoxification enzymes NAD(P)H dehydrogenase, quinone 1 (NQO1), and GSTs (that are downstream targets of Nrf2) in stomach, small intestine, and liver tissues of wild-type mice, but not in Nrf2 KO mice [69]

The ineffective defence mechanism cannot neutralize ROS overproduction in thyroid cancer cells, leading to OxS (122)