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Biomed Pharmacother 114:108863

Additionally, Zhu et al

Symptomatic treatment of fever

M.ChirilloR.AversaI.SaccoA.CostanzoF.BiamonteF

After 28 days, you must throw away (discard) your vial with unused solution

As such, most approaches to delivery have utilized gene therapy methods with the hope that the growth factor will be expressed in the correct location at a high enough concentration and for a long enough period to provide clinical relief