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Ionizing radiation can cause direct damage to proteins, DNA, and lipid membranes

James RW, Hochstrasser D, Tissot JD, Funk M, Appel R, Barja F, Pellegrini C, Muller AF, Pometta D

GSK3 directly regulates at least forty known downstream substrates that participate in a diverse range of cellular processes [172]

Unfortunately, it seems to be limited , or to quote a great article from the Journal of Cosmetic Dermatology "topically applied ascorbyl phosphate salts are, at very best, poorly absorbed in comparison with AA"

Quercetin, luteolin, and apigenin can prevent NLRP3 inflammasome assembly, activate caspase-1, and cleave Gasdermin D (GSDMD) through reactive oxygen species (ROS) scavenging or Nrf2/HO-1 activation, thereby decreasing IL-1 secretion, inhibiting macrophage pyroptosis, and suppressing macrophage-driven inflammation (9496)