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Acknowledgements This work is supported by the National Natural Science Foundation of China (22172008, L.F

doi: 10.1007/BF00400095 39 ZhangX.ZhaoY.ZhangM.PangX.XuJ.KangC.et al

doi: 10.3389/fphar.2022.1071897 Received 17 October 2022 Accepted 16 November 2022 Published 24 November 2022 Volume 13 - 2022 Edited by Chunpeng (Craig) Wan, Jiangxi Agricultural University, China Reviewed by Hui Wang, University of Massachusetts Medical School, United States Fei Yuan, Baylor College of Medicine, United States Updates Copyright 2022 Zhang, Lei, Huang and Wang

10.1016/j.ajp.2021.102691

In 60% of patients with epilepsy, symptoms are initiated by structural causes, such as traumatic brain injury (TBI) or stroke (1, 11), which are generally considered change blood-brain barrier (BBB) permeability