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Description

Wetherill, Y

Morphological characteristics include reduced volume of mitochondria, increased bilayer density, reduction or absence of mitochondrial ridges, and smaller cells separated from one another (1921), while biochemical characteristics include glutathione depletion, reduced activity of glutathione peroxidase 4 (GPX4), and Fe 2+ which generate large amounts of reactive oxygen species in a Fenton reaction, contributing to lipid peroxidation and causing ferroptosis (22, 23)

Nature Communications 14 (1), 7237

[51] Clostridium kluyveri NAD-dependent 4-hydroxybutyrate dehydrogenase (4hbd) EC 1.1.1.61 Citrobacter freundii and Klebsiella pneumoniae 1,3-propanediol dehydrogenase EC 1.1.1.202 (gene dhaT) Bacillus methanolicus NAD-dependent methanol dehydrogenase EC 1.1.1.244 [52] E