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Similar to the effect on cartilage cells, in vitro studies have demonstrated cytotoxic effects of local anaesthetics such as lidocaine and bupivacaine on tenocytes (tendon cells)

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Briefly, cell pellets obtained after biopsy mincing were washed four times with 1.5 mL of phosphate buffered saline (pH 7.2), in order to remove any recipient blood and extracellular fluid contamination

Lactobacillus and Bifidobacterium species that are everyday popular probiotic bacteria have mucosal trophic effects including stimulation of epithelial barrier function, inhibition of pathogen adhesion, regulation of existing microbiota and modulation immune system components (Shanahan, 2010