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Disruptions to this temporal architecture, whether through genetic mutations, lifestyle factors, or social disconnection, can accelerate the hallmarks of aging and compromise physiological homeostasis, as seen in natural aging

Supporting information S1 Fig

elegans lifespan in a NHR-49/PPARalpha-dependent manner

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24 Hypoxia-induced mROS stabilize the oxygen-sensitive HIF- subunit by dimerization with HIF- and induce the expression of pro-angiogenic genes

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