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This depth of human trial evidence provides greater confidence in safety characterization compared to peptides with primarily theoretical or animal-based safety data

doi: 10.1021/acs.jmedchem.7b00389

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In a model of LLC CAC, tumor-derived parathyroid-hormone-related protein (PTHrP) could promote an energy wasting state by reprogramming a thermogenic state in adipose tissue, which involved the upregulation of lipolytic enzymes (221)