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Recommendation 5: Liver biopsy should be considered in HCC patients receiving molecular targeted therapy and/or ICIs under the following conditions: (1) Liver injury cannot be clearly attributed to anti-tumor therapy, necessitating further investigation

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Approximately 8085% of absorbed iron is transported by transferrin to the reticuloendothelial system or to bone marrow for incorporation into hemoglobin, stored in the liver or muscle, or used for heme synthesis [2]

Topical formulations are designed for localized treatment, whereas transdermal systems are intended to achieve systemic effects

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