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Strategies that deplete GSH, such as using inhibitors like BSO which is inhibitor of -glutamylcysteine synthetase (-GCS) , the rate-limiting enzyme in glutathione (GSH) synthesis or by combining prodrug activation with GSH depletion in nanosystems, have shown promise in overcoming MDR and improving chemotherapy effectiveness [72]

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The loss of pericytes around ECs is common in DR and is attributed to the damaging effects of CH.Citation 38 It is believed that the angiopoietin-TIE2 system is largely responsible for the normal interaction between ECs and pericytes to stabilize vasculature

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