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Use with Angiotensin-Converting Enzyme Inhibitors: The use of angiotensin-converting enzyme inhibitors to control hypertension in patients on azathioprine has been reported to induce anemia and severe leukopenia

Currently there are still existing gaps of knowledge in terms of the state of dysbiosis in the microbiota in IBS and the pathophysiological mechanisms whereby targeted therapies can mitigate these imbalances

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As all cells in the body require cobalamin for single carbon metabolism, it has been hypothesized that cobalamin deficiency may actually contribute to the clinical signs and manifestations of gastrointestinal disease in some patients

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doi: 10.1016/S1470-2045(13)70549-7 14 KawamotoYYukiSSawadaKNakamuraMMutoOSogabeSet al