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In the last years, several reports have shown that sublethal concentrations of ROS trigger a retrograde response that not only increases lifespan in different animal models, from worms to mammals, but also enhances healthspan, particularly improving metabolism and immune system 51,71,72,73

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Pharmacology 79(1):3441 Dhir A (2019) An update of cyclooxygenase (COX)-inhibitors in epilepsy disorders [J]

GCLM Knockdown Studies RNAi was performed by using siRNA purchased from Dharmacon specific to GCLM

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Conversely, dysbiosis of gut microbiota could enhance susceptibility to pulmonary diseases and potentially act as causative agents for respiratory infections