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Recent studies have revealed the elevation of SIRT1 in a rat model of status epilepticus, a common neurological emergency which is defined as a prolonged seizure with at least five minutes or multiple seizures with incomplete recovery of consciousness [117] and its neuroprotection is conducted via deacetylation of proliferator-activated receptors and coactivator 1 (PGC-1), an important regulator for mitochondrial biogenesis [118, 119]

Known for its ability to enhance skin repair, GHK-Cu promotes collagen synthesis, which is crucial for maintaining youthful, plump skin

These functions provide new insights into the AS-IV targeted treatment of glomerular-related diseases (135)

These observations suggest that anti-neurogenic therapy by targeting NGF gene has great potential for pancreatic cancer treatment

In addition, reduced serum testosterone levels in men with DM are an independent factor of endothelial dysfunction, contributing to vascular disease and ED [78], and evidence also showed a decrease in circulating EPC correlates with penile endothelial dysfunction and testosterone levels in DM-associated ED [79]

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