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Cognitive behavioral therapy Drug therapy First-line antidepressants: selective serotonin reuptake inhibitors (SSRIs) eg, fluoxetine (Prozac) and citalopram (Celexa), serotonin-norepinephrine reuptake inhibitors (SNRIs) eg, duloxetine (Cymbalta) and venlafaxine (Effexor), and atypical antidepressants eg, bupropion (Wellbutrin) and mirtazapine (Remeron) Second-line antidepressants, including: tricyclic antidepressants eg, amitriptyline (Elavil) and clomipramine (Anafranil) monoamine oxidase inhibitors (MAOIs) eg, tranylcypromine (Parnate) and phenelzine (Nardil) Atypical antipsychotics: eg, aripiprazole (Abilify) and quetiapine (Seroquel) Neurostimulation techniques Electroconvulsive therapy Vagus nerve stimulation Repetitive transcranial magnetic stimulation Ablative neurosurgery What are Some Emerging Treatments for Depressive Disorders

As well, MPTP, a widely used toxin, is effective in inducing Parkinsonism in both rodents and primates, based on its ability to induce persistent symptoms akin to PD in humans (Davis et al

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Interestingly, a recent study examining the time-dependent effect of low IGF-1 levels on aging outcomes observed that a targeted reduction in liver-derived IGF-1 early (10 d or 5 mo) or later in life (15 mo) improved aspects of lifespan in females, though these effects were most pronounced when IGF-1 was reduced at 5 mo old 19