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Vorinostat, belinostat, and panobinostat are pan-HDAC inhibitors, whereas chidamide is a selective HDAC13 and HDAC10 inhibitor

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Tregs mediate immunosuppression by expressing FOXP3 to downregulate NFAT/NF-B signaling, thereby inhibiting effector cytokines (e.g., IL-2) and immune responses [34]

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