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HIF-1 regulates SLC7A11 and ACSL4 to modulate ferroptosis sensitivity in renal ischemia-reperfusion injury

Cancer Cell Int (2020) 20(1):16

When CKD progresses to end-stage renal disease (ESRD), renal replacement therapy, such as hemodialysis and peritoneal dialysis, is needed

Activation of CB receptors regulates anti-inflammatory responses, as evidenced by an increased release of the anti-inflammatory cytokine IL-10 and a decreased release of pro-inflammatory cytokines IL-12 and IL-23 upon CB2 receptor activation in activated macrophages (Figure 2) [84,85]

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

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