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Trastuzumab emtansine (T-DM1) performed better than capecitabine plus lapatinib in terms of efficacy and safety, in a Phase 3 study of 991 patients with previously treated HER2 + MBC, 88 leading to the FDA approval of T-DM1 in 2013

8.2 Mitochondrial complex II and epilepsy Mitochondrial complex II, also known as succinate dehydrogenase (SDH) or succinate-ubiquinone oxidoreductase (SQR), Comprises four structural subunits: SDHA, SDHB, SDHC, and SDHD, all encoded by nDNA

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No significant differences were observed in liver-related mortality by region

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