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However, the inhibition of p-AKT by AZD5363 induced c-MET phosphorylation and the levels of p-c-MET remained unchanged when the cells were treated with TGF- in the presence of AZD5363 (Fig

Mito-Q supplementation of in vitro maturation or in vitro culture medium improves maturation of buffalo oocytes and developmental competence of cloned embryos by reducing ROS production

Drug repurposing represents an attractive avenue in drug discovery due to its relatively low cost and fewer safety concerns

It is important to note that oxidative damage to DNA caused by ROS can lead to the oxidation of purines and pyrimidines, as well as the formation of apurinic/apyrimidinic sites, resulting in single-strand breaks (Maleki et al., 2024)

J Neurol Neurosurg Psychiatry 92:510518 Shi G, Zhou J, Huang K, Bi FF (2022) Trends in global amyotrophic lateral sclerosis research from 2000 to 2022: a bibliometric analysis

Statistical analysis Data were analyzed using SPSS 13.0 software and plotted as mean standard deviation