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To identify the target that mediates this effect, we applied thermal proteome profiling (TPP) and uncovered the disulfide reductases GSR and TXNRD1 as LCS3 targets

Hydrogen peroxide is known to be a short-lived molecule in cell cultures that is degraded within 30 min

Hoffman, J

The calibration of the size-exclusion column was performed with the following molecular weight markers: blue dextran (2 MDa), thyroglobulin (670 kDa), ferritin (440 kDa), aldolase (158 kDa) and ovalbumin (44 kDa)

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