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The tight junctions are formed in the endothelial cells through junction protein complexes that reduce paracellular transport [46], preserving CNS homeostasis through permitting the passage of certain nutrients into the brain tissue, reducing the entrance of toxic xenobiotic molecules and providing the efflux of toxic substances, metabolites and waste products [47, 48]

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Dong J, Wang X, Xu C, Gao M, Wang S, Zhang J, Tong H, Wang L, Han Y, Cheng N, Han Y