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When DCs lack HIF-1, they express lower levels of the co-stimulatory molecules, CD80, CD86 and CMHII, suggesting that HIF-1 plays a pivotal role in the antigen presentation

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In the SURMOUNT-1 extension study, participants who stopped tirzepatide regained approximately two-thirds of their lost weight within one year

New biomarkers associated with disulfidptosis can be used to predict prognosis and therapeutic target in clinical diagnosis and treatment of HCC [57]

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For example, pregnant and breastfeeding women may need more vitamin B12, and older adults may have difficulty absorbing the vitamin from their diet and may require higher doses