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The HDACis discussed in this review are targeting one or multiple classes, constituted of several HDAC proteins: epigenetic drugs targeting class I (HDAC1, 2, 3 and 8), class IIa (HDAC4, 5, 7 and 9) and/or class IIb (HDAC6 and 10) (Fig

We identified 10,139 and 16,104 differentially expressed genes (DEGs) at 3 h and 10 h, respectively, between hpr1-1 and Col-0 (Fig

Sirtuin 1 protects the aging heart from contractile dysfunction mediated through the inhibition of endoplasmic reticulum stress-mediated apoptosis in cardiac-specific Sirtuin 1 knockout mouse model

The cytochromes involved include CYP2D6, CYP2C19, CYP2C18, the CYP3A family, CYP1A2, CYP2C9, and CYP2B6, with the first two enzymes having a higher affinity for most antidepressants than the rest of the enzymes (Koyama et al., 1997

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