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[DOI] [PubMed] [Google Scholar] Ondo WG, Shinawi L, Davidson A, Lai D

Mechanistically, PA reduces the expression of GPX4 and heat shock factor 1 and regulates the transcription of genes related to iron metabolism (such as FTH, TFR1, and SLC40A1), causing iron homeostasis imbalance, while GPX4 overexpression reverses PA-induced ferroptosis in cardiomyocytes

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Selenium and alpha-lipoic acid (ALA) also support glutathione recycling

BPC 157, Robert's cytoprotection and Selye's stress-coping response

Physical activities, psychological disturbances, metabolic changes, emotional stress, trauma, emotion, surrounding environment and genetic off spring may contribute in early ageing [41-43]