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Executive Order 13175 VIII

10.1007/s10815-011-9590-0 384 XuM.FengT.LiuB.QiuF.XuY.ZhaoY.et al (2021)

Although reduced protein stability promotes amyloid formation, it alone cannot fully explain disease onset, as pathology is also influenced by external factors

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This theory has been augmented by several studies that demonstrated increased markers of oxidative stress (by-products of non-enzymatic lipid peroxidation) in children suffering from konzo as well as documentation of deficiencies in micronutrients which are required to maintain effective antioxidant response in konzo-prone populations 18,19