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Air-dried rhizosphere soil samples were similarly analysed, but digested with 6 mL HNO 3 (70%) and 3 mL HCl (30%)

Autophagy in a mouse model of distal myopathy with rimmed vacuoles or hereditary inclusion body myopathy

doi: 10.1038/s41590-022-01376-y 110 ZengQWangSLiMWangSGuoCRuanXet al

More critically, the generation of abundant autophagosomes significantly increases their fusion frequency with lysosomes, resulting in excessive burden and ultimate depletion of the lysosomal enzyme system whilst compromising lysosomal membrane structural integrity [87]

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Notably, histological analysis at this time point revealed no significant hepatocyte damage, suggesting that the rapid decrease in hepsin protein levels may primarily result from the activation and subsequent degradation of the hepsin serine protease in response to APAP-induced hepatotoxicity