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Graphical abstract Similar content being viewed by others Background Nephropathic cystinosis is a rare, autosomal recessive lysosomal storage disease with an incidence of 1:100,000 to 1:200,000 live births [1]

Proteins can come from animal source s such as eggs, meat or dairy products, or from plant sources

Metformin induces pyroptosis in leptin receptor-defective hepatocytes via overactivation of the AMPK axis

Studies also suggest that these nutrients support methylation pathways, which are often disrupted in ASD, thereby improving gene expression and reducing oxidative stress

Interestingly, Percival and investigators [499] reported that sodium bicarbonate supplementation resulted in significantly higher levels of PGC-1-, a key protein known to drive mitochondrial adaptations

However, Cu can also be toxic to cells because of its redox properties and ability to disrupt the active sites of metalloproteins such as Fe-S enzymes