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As a detoxifying agent, it can also prove helpful for people suffering from toxicity or fatigue

In addition, NRF2 also regulates the expression of ferritin subunits to promote free Fe 2+ sequestration, which can inhibit Fe 2+ -dependent free radical generation, and thus reducing the Fe 2+ -mediated toxicity [36]

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A yeast two-hybrid (Y2H) screen using cytoplasmic or luminal fragment of TMEM106B for bait and a prey library derived from human adult brain has identified TMEM106C, the endocytic adaptor proteins, AP2M1 and CLTC, and the vacuolar protein sorting proteins, VPS11 and VPS13D as N-terminal TMEM106B-binding proteins, although the functional importance of these interactions remains to be determined [134]