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Despite its explanatory potential, the murburn model remains a subject of vigorous debate, necessitating rigorous experimental validation for its proposed catalytic paradigm

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For instance, germline mutation in DNMT3A led to Tatton-Brown-Rahman syndrome (Yokoi et al., 2020), with some patients suffering from mild to severe intellectual disability

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Ganoderma polysaccharide and chitosan synergistically ameliorate lipid metabolic disorders and modulate gut microbiota composition in high fat diet-fed golden hamsters

(2002) Moderate iron overload enhances lipid peroxidation in livers of rats but does not affect NF-B activation induced by the peroxisome proliferator, Wy-14,643. J Nutri 132: 2525-2531