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We discovered that HSA, IgG and the majority of other human plasma proteins are transformed into potent inducers of the neutrophil respiratory burst specifically by N-chlorination [37], the same mechanism by which bacteria were found to employ novel chaperones to protect their proteins against HOCl-stress-induced aggregation [15, 16] (Fig

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Readers are encouraged to refer to other relevant reviews that focus on this important area 31,32,33

For example, the activation of the rate-limiting enzyme HMG-CoA reductase (HMGCR) in cholesterol biosynthesis shows circadian rhythm ( + biosynthesis (Ramsey et al., 2009)

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