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Description

Jackowski, Biochim

Individual response varies, and treatment should be guided by actual results rather than rigid adherence to any particular schedule

Various small-molecule inhibitors targeting different stages of NLRP3 activation have been developed and investigated preclinically

While human studies remain scarce, emerging in vitro models simulating human gut conditions reveal variable microbiota responses to MPs, ranging from dysbiosis and inflammatory metabolite production to probiotic enrichment and metabolic adaptation (Fournier et al., 2023