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while this might seem counterintuitive, given that leptin is known to promote osteoblastic differentiation and enhance bone formation [178, 179], it should be noted that patients with obesity generally exhibit a condition of leptin resistance, characterised by a decreased peripheral activity of leptin despite increased serum levels, making it difficult to ascertain its actual impact on bone health in these patients

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As a hydrophilic protic solvent with a dielectric constant of 6.2, it is capable of dissolving a wide range of polar and non-polar compounds including salts, sugars, oils, sulfur, and iodine

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