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However, their guidelines are neither clinical nor evidence-based

Immune checkpoint proteins are well known in the art and include, but are not limited to, CTLA-4, PD-1, VISTA, B7-H2, B7-H3, PD-L1, B7-H4, B7-H6, ICOS, HVEM, PD-L2, CD200R, CD160, gp49B, PIR-B, KRLG-1, KIR family receptors, TIM-1, TIM-3, TIM-4, LAG-3(CD223), IDO, GITR, 4-IBB, OX-40, BTLA, SIRPa (CD47), CD48, 2B4(CD244), B7.1, B7.2, ILT-2, ILT-4, IT, TIGLA 2, butyrophilin, and A2aR (see, e.g., WO 2012/177624)

(2) This stimulating effect also triggers the release of adrenaline, a hormone responsible for the bodys fight or flight response

The mechanism involves an increase in GLUT4 transporter expression, improving glucose uptake

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