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2 Metformin-like compounds occur naturally in the plant Galega officinalis , and whilst it was used in medieval Europe to treat a variety of conditions, the plant is highly toxic with a potential to induce hypotension

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In previous large-scale clinical trials of GLP-1RAs, 15.2% ( n = 618) of AMPLITUDE-O and 6.1% ( n = 575) of Harmony Outcomes patients used SGLT2is at baseline [18, 20] (Table 1)

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