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The ratio of higher plasma and lower urinary solute acid concentrations to plasma concentrations was independently associated with cardiovascular and all-cause mortalities in patients with diabetic kidney disease

The clinical spectrum is very heterogeneous, ranging from hypoketotic hypoglycemia, liver dysfunction, rhabdomyolysis, cardiomyopathy and early demise

Xanthine dehydrogenase, an enzyme involved in purine metabolism, is converted to xanthine oxidase that generates superoxide under ischemic conditions in cardiovascular systems [4]

Briefly, ferroptosis-prone PUFAs contain bis-allylic hydrogen atoms that are liable to removal from the PUFA scaffold, exposing carbon moieties that can react with ferric iron or oxygen radicals either directly, or subsequent to attachment of molecular oxygen, form lipid (hydro)peroxides

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