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Supplementary material For supplementary material accompanying this paper visit Acknowledgements The authors would like to thank the Clinical Research Development Unit of Baqiyatallah Hospital, for all their support and guidance during carrying out this study

However, the conclusions that can be drawn from the included studies are significantly limited given small sample size, limited follow-up time, and a lack of control groups

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Its Innovative Science and Technology Approaches for New Drugs (ISTAND) pilot program is explicitly considering complex in vitro models like OoCs, with a liver-on-chip for DILI being the first OoC accepted into the program for evaluation (222)