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2.2.5 Study from Spain Notably, the level of growth differentiation factor-15 (GDF-15) was found to be higher in DCM patients with type 2 diabetes in a study from Spain ( 2.2.6 Studies from China The concentration of annexin A2, which is a calcium-dependent phospholipid-binding protein, was found to be higher in the serum of DCM patients, in a study from China, and was negatively associated with systolic and diastolic functions of the heart, and this may help in early diagnosis of DCM (He et al., 2023)

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Managing side effects Side effects are common, especially during dose escalation

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Coptis japonica contains berberine, a potent natural antibacterial and anti-inflammatory compound