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One is that it doesnt add to the pill burden that many people 50 and older experience, Promer says

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Conservative approaches encompass oral therapy with colchicine, potassium para -aminobenzoate, tamoxifen, antioxidants, phosphodiesterase-5 inhibitors, and so on

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4.1 Future directions: strengths, limitations and potential therapeutic interventions All literature highlighted and discussed in this review highlights some of the research that has been conducted examining the relationship between mitochondria and the gut microbiome, but it is clear that further research is required before we can utilize this relationship as a therapeutic intervention in primary mitochondrial diseases