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E.AnglicaV

10.1165/rcmb.2022-0345OC 67 HetzC.PapaF

Sildenafil and vardenafil, types 5 and 6 phosphodiesterase inhibitors, induce caspase-dependent apoptosis of B-chronic lymphocytic leukemia cells

First, in non-malignant tissues, PDK isoforms play essential physiological roles, particularly in highly energy-demanding organs such as the heart and skeletal muscle, where they regulate substrate utilization by limiting carbohydrate oxidation and promoting metabolic flexibility [190, 191]

found that fosinopril (FOS), a TLR4 inhibitor, can inhibit NF-B signaling in both in vivo and in vitro models