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Murine studies show no acute toxicity at doses up to 100 mg/kg, and the Nature Metabolism paper reported no adverse metabolic effects during the 11-week treatment period

10.1016/S0952-7915(03)00042-6 131 RischM.MeierD

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Serious adverse events appear rare in community reports, though underreporting of problems remains possible

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We did not propose the RUC-recommended direct PE inputs for these codes because of the insufficient number of survey responses, and further, we did not agree with some of the RUC's refinements to the direct PE inputs for this service