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However, TMZ sensitivity is significantly affected by the level of O 6 -methylguanine-DNA methyltransferase, which can remove TMZ-induced alkylation from nucleotides and has been employed as a predictor of responsiveness to alkylating drugs (Tomar et al

Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1xGTP pathway

Overmethylation, a condition characterized by an excessive addition of methyl groups to DNA, RNA, proteins, and neurotransmitters, can result from a complex interplay of genetic, environmental, and dietary factors

Strengths and limitations The strengths of our study are as follows: (1) We performed a robust, streamlined proteomics method to quantify proteins in the human serum using nano UHPLC-MS/MS 15

We thank Junqing Wu and Zhongquan Lin for technical assistance

H 2 O 2, which is not converted to H 2 O, can form reactive hydroxyl radicals (OH) when reacted with transition metal ions (Fe 2++ /Cu)