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Nothing here is medical advice or a dosing recommendation.

It serves as a cofactor for the methionine synthase enzyme, which transfers methyl groups to enable the regeneration of methionine from homocysteine

specialist advice should be sought if this condition is suspected

A 2025 European Journal of Clinical Nutrition commentary on the NICE guideline argued that the diagnostic threshold and clinical awareness still need to be tightened further, especially around pernicious anaemia, which is still under-recognised in primary care