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Sulfation and oxidation increased, while glucuronidation decreased following excessive administration of APAP (6.0 mM/h)

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GHK as a copper-binding peptide GHK binds copper(II) through coordination by the N-terminal amino group of glycine, the imidazole nitrogen of histidine, and the deprotonated amide nitrogen of the Gly-His peptide bond, forming a stable square-planar (or square-pyramidal) complex