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Using in silico design, structureactivity relationships (SARs), chemical optimization, cell-based assays and in vivo experiments, we identified and characterized the first-in-kind small-molecule inhibitors of STX7Munc13-4-dependent endosomal maturation and signaling for use in immune cells that contribute to systemic inflammation

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Contraindications Based on mechanisms and theoretical considerations, BPC-157 may not be appropriate for: Individuals with active cancer Pregnant or breastfeeding women Those with uncontrolled cardiovascular conditions People taking anticoagulant medications (effects on bleeding unknown) Individuals with autoimmune conditions (immune modulation effects unclear) Quality and Purity Concerns Perhaps the most significant safety concern involves product quality

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Data availability statement The data underlying this article will be shared on reasonable request to the corresponding author

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