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We and others have shown that interaction of TFEB and TFE3 with active Rags GTPases is required for recruitment of the transcription factors to the lysosome surface and subsequent mTORC1 phosphorylation (Martina et al, 2014

GHK copper complexes have been examined in skin and extracellular matrix research, often in connection with collagen associated gene expression and oxidative stress markers, while KPV has been explored in models focused on cytokine signaling and barrier integrity