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& Kang, R

[21] Trimethylaminuria [edit] Trimethylaminuria is an autosomal recessive genetic disorder involving a defect in the function or expression of flavin-containing monooxygenase 3 (FMO3) which results in poor trimethylamine metabolism

Once in the bloodstream, ALCAR plays a fundamental role in the production of energy, acting as the catalyst for the beta-oxidation of long chain fatty acids by the mitochondria

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However, cardiac-specific deletion of the mitochondrial pyruvate carrier (MPC), which imports glucose and lactate metabolites into the mitochondria, results in age-dependent cardiac hypertrophy, a condition characterized by an increase in heart and individual cardiomyocyte sizes [188] , and cardiomyopathy in mice [189,190]