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In addition, the use of mTOR inhibitors can inhibit EMT and the expression of NGF which were promoted by the activation of HGF/c-Met signaling pathway (Supplementary Figs

These pathways contribute to the enhancement of compound polarity and water solubility, facilitating their excretion from the organism

However, silencing the expression of endogenous ATF4 using a small interfering RNA (siATF4) significantly increased the cell proliferation inhibition rate (Figure 6A)

Symptom improvement is seen in a subset of patients, but the majority show no improvement or worsening of symptoms despite treatment or attack resolution