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Both formulations were identical in appearance and texture, and participants were blinded to which formulation contained the active ingredient

doi: 10.1038/nm.2682 4 CollinF

This observation is not surprising as PDI knockdown would reduce the overall cellular pools of both reduced and oxidized forms of PDI, and the decreased availability of the oxidized PDI would decrease the signalling strength stemming from oxidized PDI-mediated NOS dimerization ( i.e